Novel short-step synthesis of functionalized γ-phenyl-β-hydroxybutenoates and their cyclization to 4-hydroxycoumarins via the N-hydroxybenzotriazole methodology

…, A Detsi, O Igglessi-Markopoulou, J Markopoulos

文献索引：Athanasellis, Giorgos; Melagraki, Georgia; Chatzidakis, Haralambos; Afantitis, Antreas; Detsi, Anastasia; Igglessi-Markopoulou, Olga; Markopoulos, John Synthesis, 2004 , # 11 p. 1775 - 1782

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被引用次数: 12

摘要

Abstract A novel method for the synthesis of functionalized 3-substituted 4- hydroxycoumarins is reported. C-Acylation compounds were derived from the reaction of the N-hydroxybenzotriazole ester of the functionalized acetyl salicylic acids and a variety of active methylene compounds and cyclized to the title compounds. The synthesis is simple and the compounds are produced in yields varying from 39 to 80%. The structure of the ...