An ultimate and general model describing the interaction between opioid ligands and μ- opioid receptors is not available yet, so the mode of action of atypical peptide analogues or peptidomimetics is worthy of investigation. In this context, the peptide c [-Tyr-d-Pro-d-Trp- Phe-Gly-] was observed to act as an agonist toward μ-opioid receptors with appreciable potency, albeit deprived of a protonable nitrogen. This compound was synthesized as a ...
[Belokon', Yu. N.; Zel'tzer, I. E.; Bakhmutov, V. I.; Saporovskaya, M. B.; Ryzhov, M. G.; et al. Journal of the American Chemical Society, 1983 , vol. 105, # 7 p. 2010 - 2017]
