N-thiolated β-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus

…, B Heldreth, TE Long, S Jang, E Turos

文献索引：Revell, Kevin D.; Heldreth, Bart; Long, Timothy E.; Jang, Seyoung; Turos, Edward Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2453 - 2467

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被引用次数: 30

摘要

This study focuses on the mechanism of action of N-alkylthio β-lactams, a new family of antibacterial compounds that show promising activity against Staphylococcus and Bacillus microbes. Previous investigations have determined that these compounds are highly selective towards these bacteria, and possess completely unprecedented structure–activity profiles for a β-lactam antibiotic. Unlike penicillin, which inhibits cell wall crosslinking ...