Efficient synthesis of the 3'-phenolic metabolite of paclitaxel

SH Krishna Reddy, S Lee, A Datta…

文献索引：Reddy, S. Hari Krishna; Lee, Stephen; Datta, Apurba; Georg, Gunda I. Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8211 - 8214

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被引用次数: 23

摘要

Paclitaxel (1; Taxol) and docetaxel (2; Taxotere) have emerged as two of the most effective antitumor agents in a variety of malignancies. 1-5 Acting via a similar mechanism of action, both these drugs bind to tubulin, leading to microtubule stabilization, mitotic arrest, and subsequent cell death. Despite the great similarity in the chemical structures and their mode of action, the metabolic profile of paclitaxel and docetaxel was found to be quite different. ...