Design and synthesis of new potent, silent 5-HT 1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors

…, I Pallard-Sigogneau, C Fourrier, P Chopin…

文献索引：Perez; Pauwels; Pallard-Sigogneau; Fourrier; Chopin; Palmier; Colovray; Halazy Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 23 p. 3423 - 3428

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被引用次数: 26

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Hybrid molecules built up by covalent coupling of aminopropanol derivatives (especially pindolol) with antidepressant drugs like fluoxetine, paroxetine or milnacipran were found to be potent and silent 5-HT 1A antagonists (K B < 1 nM for 7c and 9a). ... Compounds 7c and ...