Pseudopeptide analogs of substance P and leucine enkephalinamide containing the. psi.(methyleneoxy) modification: synthesis and biological activity

E Roubini, R Laufer, C Gilon, Z Selinger…

文献索引：Roubini; Laufer; Gilon; Selinger; Roques; Chorev Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2430 - 2438

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被引用次数: 33

摘要

The isosteric methyleneoxy 9 (CH20) function was employed as a novel peptide-bond surrogate and incorporated into sequences of two neuropeptides, substance P (SP) and enkephalin. A pseudopeptide analogue [pGlue, PhesO (CHzO) Gl~] SP,+ ll (7) of SP related C-terminal hexapeptide [pGlu6] SPbll and two pseudopeptide analogues of [Ledlenkephalinamide,[Tyr19 (CH20) Gly2, Leu6] enkephalinamide (11) and [Gly20 ( ...