The Journal of organic chemistry

Versatile acylation of N-nucleophiles using a new polymer-supported 1-hydroxybenzotriazole derivative

IE Pop, BP Déprez, AL Tartar

文献索引：Pop, Iuliana E.; Deprez, Benoit P.; Tartar, Andre L. Journal of Organic Chemistry, 1997 , vol. 62, # 8 p. 2594 - 2603

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被引用次数: 107

摘要

The synthesis of a new polymer-supported coupling reagent derived from 1- hydroxybenzotriazole is described. An aminomethylated polystyrene was functionalized by reaction with 3-nitro-4-chlorobenzenesulfonyl chloride (2) followed by treatement with hydrazine hydrate, to give the polymeric N-benzyl-1-hydroxybenzotriazole-6-sulfonamide (4). The polymeric reagent 4 was shown to be highly efficient for the synthesis of amides. ...