One??Pot Synthesis of Diazine??Bridged Bisindoles and Concise Synthesis of the Marine Alkaloid Hyrtinadine A

BOA Tasch, E Merkul, TJJ Müller

文献索引：Tasch, Boris O. A.; Merkul, Eugen; Mueller, Thomas J. J. European Journal of Organic Chemistry, 2011 , # 24 p. 4532 - 4535

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被引用次数: 16

摘要

Abstract Diazine-bridged bisindoles are readily obtained from N-Boc-protected 3- iodoindoles and 3-iodo-7-azaindole in a pseudo three-component reaction involving a one- pot Masuda borylation–Suzuki arylation sequence. Some of the title compounds display promising cytotoxic properties. The versatility of this methodology is illustrated by a very concise total synthesis of the marine alkaloid hyrtinadine A.