δ-Carbolines and their ring-opened analogs: Synthesis and evaluation against fungal and bacterial opportunistic pathogens

…, JR Etukala, MR Jacob, SI Khan, LA Walker…

文献索引：Mazu, Tryphon K.; Etukala, Jagan R.; Jacob, Melissa R.; Khan, Shabana I.; Walker, Larry A.; Ablordeppey, Seth Y. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2378 - 2385

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被引用次数: 14

摘要

Abstract Previous studies have indicated that the δ-carboline (2) ring system derived from the natural product cryptolepine (1) may represent a pharmacophore for anti-infective activity. This paper describes the design and synthesis of a small library of substituted δ- carbolines and the evaluation of the anti-fungal and anti-bacterial activities. An evaluation of the anti-bacterial activity of a previously reported library of ring-opened analogs was also ...