Synthesis and antifungal activity of 1, 3, 2-benzodithiazole S-oxides
…, DE Weissing, PA Lartey, SK Tanaka…
文献索引：Klein, Larry L.; Yeung, Clinton M.; Weissing, David E.; Lartey, Paul A.; Tanaka, S. Ken; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 572 - 578
The preparation of 1, 3, 2-benzodithiazole S-oxide analogs exhibiting in vitro antifungal activity against several strains of Candida is described. For the preparation of derivatives bearing aromatic substituents, a novel electrophilic aromatic thiolation reaction was utilized which produced substituted aromatic 1, 2-dithiol intermediates. The reactions of nucleophiles with the parent heterocyclic system have led to an efficient transamidation ...
