3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity

P Yogeeswari, R Thirumurugan, R Kavya…

文献索引：Yogeeswari, Perumal; Thirumurugan, Rathinasabapathy; Kavya, Ramkumar; Samuel, Jayakar Selwyn; Stables, James; Sriram, Dharmarajan European Journal of Medicinal Chemistry, 2004 , vol. 39, # 8 p. 729 - 734

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被引用次数: 43

摘要

A series of 3-chloro-2-methylphenyl substituted semicarbazones (3–33) was synthesized and evaluated for anticonvulsant and CNS activities. After intraperitoneal injection to mice or rats, the semicarbazone derivatives were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), and subcutaneous strychnine (scSTY)- induced seizure and neurotoxicity screens. The aryl urea (1) and the semicarbazide (2) ...