Synthetic Communications

Synthetic access to new pyridone derivatives through the alkylation reactions of hydroxypyridines with epoxides

A Kocak, S Kurbanli, S Malkondu

文献索引：Kocak, Ahmet; Kurbanli, Sultan; Malkondu, Sait Synthetic Communications, 2007 , vol. 37, # 21 p. 3697 - 3708

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被引用次数: 6

摘要

Abstract General methods for the preparation of a variety of pyridone and oxypyridine derivatives are described. 2??, 3??, 4??Hydroxy pyridine and 2??pyridinemethanol were alkylated with ethylene??, propylene??, and stryrene??oxide and epichlorohydrin in the presence of different Lewis acids as a catalyst. The best yield of 3a was achieved in the presence of CdI2/BF3· OEt2. The corresponding pyridone derivatives (3a–d, 7a–d) were ...