Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol Synthesis A Caveat on Reaction Times and Product Isolation
…, JM Neudörfl, H Gröger, A Berkessel
文献索引：Berkessel, Albrecht; Harnying, Wacharee; Duangdee, Nongnaphat; Neudoerfl, Joerg-M.; Groeger, Harald Organic Process Research and Development, 2012 , vol. 16, # 1 p. 123 - 128
Aldol reactions with trifluoroacetophenones as acceptors yield chiral α-aryl, α-trifluoromethyl tertiary alcohols, valuable intermediates in organic synthesis. Of the various organocatalysts examined, Singh's catalyst [(2 S)-N-[(1 S)-1-hydroxydiphenylmethyl-3-methylbutyl]-2-
