Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist leucettamine A and related analogs

JC Boehm, JG Gleason, I Pendrak…

文献索引：Boehm; Gleason; Pendrak; Sarau; Schmidt; Foley; Kingsbury Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3333 - 3340

全文：HTML全文

被引用次数: 28

摘要

The isolation and structure determination of the naturally occurring LTB4 receptor antagonist Leucettamine A (1) was recently rep0rted. l Herein we describe the synthesis of this natural product, the preparation of several analogues, and their effectiveness as antagonists of I3H1LTB4 binding to intact human U-937 cells. Total synthesis of Leucettamine A (1) is achieved by a convergent route which takes advantage of the elements of symmetry within ...