Widely Applicable Synthesis of Enantiomerically Pure Tertiary Alkyl??Containing 1??Alkanols by Zirconium??Catalyzed Asymmetric Carboalumination of Alkenes and …
S Xu, CT Lee, G Wang, E Negishi
文献索引：Xu, Shiqing; Lee, Ching-Tien; Wang, Guangwei; Negishi, Ei-Ichi Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1829 - 1835
Abstract A highly enantioselective and widely applicable method for the synthesis of various chiral 2-alkyl-1-alkanols, especially those of feeble chirality, has been developed. It consists of zirconium-catalyzed asymmetric carboalumination of alkenes (ZACA), lipase-catalyzed acetylation, and palladium-or copper-catalyzed cross-coupling. By virtue of the high selectivity factor (E) associated with iodine, either (S)-or (R)-enantiomer of 3-iodo-2-alkyl-1 ...
