A facile and efficient synthesis of 14C??labelled sulforaphane

CA D'Souza, S Amin, D Desai

文献索引：D'Souza, Christopher A.; Amin, Shantu; Desai, Dhimant Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 9 p. 851 - 859

全文：HTML全文

被引用次数: 10

摘要

Abstract Isothiocyanates have gained considerable attention for their role as potent chemopreventive agents. Sulforaphane, 1a (SFN), a naturally occurring isothiocyanate, was isotopically labelled in five steps starting from 3-(methylthio)-1-propanol (2). Reacting 2 with tosyl chloride in the presence of Et 3 N yielded the tosylate 3. Gently refluxing 3 with K 14 CN in DMF gave the nitrile 4b. Reduction to the amine 5b was achieved using BH 3-THF. ...