Synthesis and biological evaluation of 4-styrylcoumarin derivatives as inhibitors of TNF-α and IL-6 with anti-tubercular activity

K Upadhyay, A Bavishi, S Thakrar, A Radadiya…

文献索引：Upadhyay, Kuldip; Bavishi, Abhay; Thakrar, Shailesh; Radadiya, Ashish; Vala, Hardevsinh; Parekh, Shrey; Bhavsar, Dhairya; Savant, Mahesh; Parmar, Manisha; Adlakha, Priti; Shah, Anamik Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2547 - 2549

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被引用次数: 30

摘要

A series of 4-styrylcoumarin have been synthesized by Knoevenagel condensation between substituted 4-methylcoumarin-3-carbonitrile and different heterocyclic or aromatic aldehydes. 4-Methylcoumarin-3-carbonitrile has been synthesized by the base catalyzed reaction between substituted 2-hydroxyacetophenone and ethyl cyanoacetate. The structures of the newly synthesized compounds were confirmed by 1H NMR, IR and mass ...