Tetrahedron

General method of obtaining deuterium-labeled heterocyclic compounds using neutral D 2 O with heterogeneous Pd/C

H Esaki, N Ito, S Sakai, T Maegawa, Y Monguchi…

文献索引：Esaki, Hiroyoshi; Ito, Nobuhiro; Sakai, Shino; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao Tetrahedron, 2006 , vol. 62, # 47 p. 10954 - 10961

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被引用次数: 54

摘要

A protocol of a versatile H–D exchange reaction of heterocyclic compounds catalyzed by heterogeneous Pd/C in D2O is described. The reaction of various nitrogen-containing heterocycles with 10% Pd/C (10wt% of the substrate) under hydrogen atmosphere in D2O as a deuterium source at 110–180° C for 24h afforded the corresponding deuterated compounds with satisfactory efficiency of deuteration in moderate to excellent isolated ...