Synthesis of Epimeric 2-Deuterioestr-4-ene-3, 17-diones

T NAMBARA, H HOSODA, T ANJYO…

文献索引：Nambara,T. et al. Chemical and Pharmaceutical Bulletin, 1972 , vol. 20, # 2 p. 287 - 294

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被引用次数: 7

摘要

In order to clarify the stereochemistry of hydrogen loss from C-2 in the 19-norsteroid during the placental aromatization the stereoselective synthesis of C-2 epimeric 2-deuterioestr-4- ene-3, 17-diones has been carried out. A key intermediate leading to the desired compounds, estr-2-ene-5βA, 17β-diol (VIII), was prepared from readily available 19- nortestosterone in several steps. Epoxidation with per-acid followed by trans-diaxial ...