Cyclic dipeptides exhibit potency for scavenging radicals

T Furukawa, T Akutagawa, H Funatani, T Uchida…

文献索引：Furukawa, Tadashi; Akutagawa, Takashi; Funatani, Hitomi; Uchida, Toshikazu; Hotta, Yoshihiro; Niwa, Masatake; Takaya, Yoshiaki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2002 - 2009

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被引用次数: 23

摘要

Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against OH and O2·-was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against OH than vitamin E. However, only cyclo (l-Cys–l-Leu) scavenged O2·-.