Design and preparation of serine–threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures. Part 3

…, AB Maude, ME O'Donnell, AP Mehrotra…

文献索引：Webster; Maude; O'Donnell; Mehrotra; Gani Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 14 p. 1673 - 1695

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被引用次数: 19

摘要

Nodularin and microcystins are complex natural cyclic isopeptidic hepatotoxins that serve as subnanomolar inhibitors of the eukaryotic serine–threonine protein phosphatases PP1 and PP2A, enzymes that are intimately involved in controlling cellular metabolism. Previously we described a solution-phase synthesis of st