A novel and simple asymmetric synthesis of CMI-977 (LDP-977): a potent anti-asthmatic drug lead

…, P Radhakrishna, CV Ramana, MS Chorghade

文献索引：Gurjar, Mukund K.; Murugaiah; Radhakrishna; Ramana; Chorghade, Mukund S. Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1363 - 1370

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被引用次数: 29

摘要

A practical gram scale asymmetric synthesis of CMI-977 is described. A tandem double elimination of an α-chlorooxirane and concomitant intramolecular nucleophilic substitution was used as the key step. Jacobsen hydrolytic kinetic resolution and Sharpless asymmetric epoxidation protocols were applied for the execution of the synthesis of the key chiral building block.