Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives

…, T Terada, M Irie, T Katsura, A Niida, K Tomita…

文献索引：Tsuda, Masahiro; Terada, Tomohiro; Irie, Megumi; Katsura, Toshiya; Niida, Ayumu; Tomita, Kenji; Fujii, Nobutaka; Inui, Ken-Ichi Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 318, # 1 p. 455 - 460

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被引用次数: 52

摘要

Abstract Midodrine is an oral drug for orthostatic hypotension. This drug is almost completely absorbed after oral administration and converted into its active form, 1-(2′, 5′- dimethoxyphenyl)-2-aminoethanol)(DMAE), by the cleavage of a glycine residue. The intestinal H+-coupled peptide transporter 1 (PEPT1) transports various peptide-like drugs and has been used as a target molecule for improving the intestinal absorption of poorly ...