Nonquaternary cholinesterase reactivators. 3. 3 (5)-Substituted 1, 2, 4-oxadiazol-5 (3)-aldoximes and 1, 2, 4-oxadiazole-5 (3)-thiocarbohydroximates as reactivators of …

CD Bedford, RA Howd, OD Dailey, A Miller…

文献索引：Bedford; Howd; Dailey; Miller; Nolen III; Kenley; Kern; Winterle Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2174 - 2183

全文：HTML全文

被引用次数: 48

摘要

As an extension of an earlier investigation (J. Med. Chem. 1984, 27, 1431), we prepared a series of 3-substituted 5-[(hydroxyimino) methyl]-l, 2, 4-oxadiazoles and the corresponding 5- thiocarbohydroximic acid 2-(N, N-dialkylamino) ethyl S-esters. The compounds were evaluated in vitro as reactivators of phosphonylated electric eel and human erythrocyte (RBC) acetylcholinesterases (AChE). The compounds were characterized with respect to ( ...