Direct metallation of thienopyrimidines using a mixed lithium–cadmium base and antitumor activity of functionalized derivatives

…, F Lassagne, G Bentabed-Ababsa, E Nassar…

文献索引：Snegaroff, Katia; Lassagne, Frederic; Bentabed-Ababsa, Ghenia; Nassar, Ekhlass; Ely, Sidaty Cheikh Sid; Stephanie Hesse; Perspicace, Enrico; Derdour, Aicha; Mongin, Florence Organic and Biomolecular Chemistry, 2009 , vol. 7, # 22 p. 4782 - 4788

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被引用次数: 16

摘要

A series of thieno [2, 3-d]-and thieno [3, 2-d] pyrimidines have been easily synthesized using as key step a deproto-cadmiation–trapping sequence. Some of the compounds thus synthesized were screened for anticancer (cytotoxic) activities, and (S)-2-(6-iodo-2- phenylthieno [2, 3-d] pyrimidin-4-ylamino)-3-phenylpropanoic acid proved to have a significant activity towards liver, human breast and cervix carcinoma cell lines.