Bioorganic chemistry

The rate of spontaneous cleavage of the glycosidic bond of adenosine

RB Stockbridge, GK Schroeder, R Wolfenden

文献索引：Stockbridge, Randy B.; Schroeder, Gottfried K.; Wolfenden, Richard Bioorganic Chemistry, 2010 , vol. 38, # 5 p. 224 - 228

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被引用次数: 11

摘要

Previous estimates of the rate of spontaneous cleavage of the glycosidic bond of adenosine were determined by extrapolating the rates of the acid-and base-catalyzed reactions to neutral pH. Here we show that cleavage also proceeds through a pH-independent mechanism. Rate constants were determined as a function of temperature at pH 7 and a linear Arrhenius plot was constructed. Uncatalyzed cleavage occurs with a rate constant of ...