Organic & biomolecular chemistry

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

ES Park, JY Dong, JS Shin

文献索引：Park, Eul-Soo; Dong, Joo-Young; Shin, Jong-Shik Organic and Biomolecular Chemistry, 2013 , vol. 11, # 40 p. 6929 - 6933

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被引用次数: 23

摘要

Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω- transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.