Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia

CJ Helal, Z Kang, X Hou, J Pandit…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4536 - 4547

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被引用次数: 33

摘要

... Journal of Medicinal Chemistry. ... With an interest in being able to examine the effect of a PDE10A inhibitor in a clinical setting, we sought to bring forward a number of structurally diverse chemical series that would increase the chances of finding a compound with the ...