Discovery of N-{(1 S, 2 S)-2-(3-Cyanophenyl)-3-[4-(2-[18F] fluoroethoxy) phenyl]-1-methylpropyl}-2-methyl-2-[(5-methylpyridin-2-yl) oxy] propanamide, a Cannabinoid- …

…, S Sanabria, X Tong, J Wang, DA Levorse…

文献索引：Liu, Ping; Lin, Linus S.; Hamill, Terence G.; Jewell, James P.; Lanza Jr., Thomas J.; Gibson, Raymond E.; Krause, Stephen M.; Ryan, Christine; Eng, Waisi; Sanabria, Sandra; Tong, Xinchun; Wang, Junying; Levorse, Dorothy A.; Owens, Karen A.; Fong, Tung M.; Shen, Chun-Pyn; Lao, Julie; Kumar, Sanjeev; Yin, Wenji; Payack, Joseph F.; Springfield, Shawn A.; Hargreaves, Richard; Burns, H. Donald; Goulet, Mark T.; Hagmann, William K. Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3427 - 3430

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被引用次数: 33

摘要

The discovery of a structurally distinct cannabinoid-1 receptor (CB1R) positron emission tomography tracer is described. Starting from an acyclic amide CB1R inverse agonist (1) as the lead compound, an efficient route to introduce 18F to the molecule was developed. ...