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Synthesis of E-and Zo-methoxy-substituted 2, 3-diphenyl propenoic acids and its methyl esters

…, M Sutyinszky, N Nagy, I Pálinkó

文献索引:Felfoeldi, Karoly; Sutyinszky, Maria; Nagy, Nora; Palinko, Istvan Synthetic Communications, 2000 , vol. 30, # 9 p. 1543 - 1553

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被引用次数: 22

摘要

Abstract A series of stereoisomeric o-methoxy-substituted 2, 3-diphenyl propenoic acids and their methyl esters have been synthesized. The E isomers were prepared by a modified Perkin condensation (substituted benzaldehyde, phenylacetic acid, Et3N/acetic anhydride). The difficult to access Z isomers were obtained conveniently in good yields when the appropriate coumarin derivatives were allowed to react with KOH and CH3I in DMSO.