Interaction of alkoxides XVIII. Utilitization of the complex base from alkyllithium and potassium alkoxides in the dimetallation of phenol, thiophenol, o-, m-and p-cresol

…, HD Verkruijsse, L Brandsma, L Lochmann

文献索引：Andringa, H.; Verkruijsse, H.D.; Brandsma, L.; Lochmann, L. Journal of Organometallic Chemistry, 1990 , vol. 393, # 3 p. 307 - 314

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被引用次数: 15

摘要

Abstract Successful O-and ortho-ring metallation of phenol and side chain metallation in o- cresol has been achieved by use of a mixture of two molar equivalents of n-butyllithium, one molar equivalent of potassium t-butoxide, and two molar equivalents of N, N, N′, N′- tetramethylethylene diamine in hexane. Poor results were obtained with m-cresol, thiophenol and p-cresol. m-Cresol was effectively dimetallated with a mixture of two molar ...