Journal of medicinal chemistry

Synthesis and antitumor activity of cyclophosphamide analogs. 1. Benzo annulated cyclophosphamide and related systems

SM Ludeman, G Zon

文献索引：Ludeman,S.M.; Zon,G. Journal of Medicinal Chemistry, 1975 , vol. 18, # 12 p. 1251 - 1253

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被引用次数: 33

摘要

Synthesis of 2-[bis (2-chloroethy~) amino]-3, 4-dihydro-2H-1, 3, 2-benzoxazaphosphorin 2- oxide (2), which is a benzo annulated analog of cyclophosphamide [2-bis (2-chloroethyl) aminotetrahydro-2H-l, 3, 2-oxazaphosphorin 2-oxide (1) I, was carried out in order to test for possible increased antitumor activity relative to 1 due to the presence of an oxidatively reactive C-4 benzylic site in 2. A structural isomer of 2, 2-[bis (2-chloroethyl) amino]-l, 4- ...