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Structure-reactivity relations for thiol-disulfide interchange

J Houk, GM Whitesides

文献索引:Houk,J.; Whitesides,G.M. Journal of the American Chemical Society, 1987 , vol. 109, p. 6825

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被引用次数: 160

摘要

Abstract: Equilibrium constants were determined for thiol-disulfide interchange between 36 di-and trithiols and the disulfides derived from either 2-mercaptoethanol or dithiothreitol. Reactions were conducted in methanol-d,/aqueous buffer (pH 7) or methanold, at 25 “C, using NMR spectroscopy to follow the reactions. These data were used to rank the dithiols in terms of reduction potential and to infer the structure of the disulfides formed from them on ...