Biologically active polycycloalkanes. 1. Antiviral adamantane derivatives

K Aigami, Y Inamoto, N Takaishi, K Hattori…

文献索引：Aigami,K. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, p. 713 - 721

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被引用次数: 64

摘要

Convenient methods for the synthesis of 1-substituted 3-adamantyl chlorides and bromides (2), 1-adamantylphenols and-cresols (3), and 1-adamantylacetic (6) as well as 1, 3- adamantanediacetic (11) acids are described. Several novel derivatives were synthesized from these key intermediates: adamantylcyclohexanols (4) and-cyclohexanones (5) from adamantylphenols (3), and esters (7, 12, and 22), amides (13 and la), thioamides (9 and ...