Abstract Reactions of 2-amino-4-phenylthiazole with aromatic aldehydes gave the corresponding Schiff bases which were reduced with sodium tetrahydridoborate to amines. Reactions of the Schiff bases with 2-methyloxirane, 2-chloromethyloxirane, and 2- phenoxymethyloxirane led to the formation of 2, 5-disubstituted 3-(4-phenylthiazol-2-yl) oxazolidines.