The synthesis of 6-substituted 2, 4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50− 95%) through SRN1 reactions, starting from commercially available 6-chloro-2, 4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2, 4- ...
