Tandem Synthesis of 3-Chloro-4-iodoisoxazoles from 1-Copper (I) Alkynes, Dichloroformaldoxime, and Molecular Iodine

…, J Zhang, B Wang, Z Zhao, X Wang…

文献索引：Wang, Bo; Zhang, Jianlan; Wang, Xinyan; Liu, Nan; Chen, Wenwen; Hu, Yuefei Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10519 - 10523

全文：HTML全文

被引用次数: 12

摘要

A tandem synthesis for structurally novel 3-chloro-4-iodoisoxazoles was developed by simply mixing 1-copper (I) alkynes, dichloroformaldoxime, and molecular iodine together. The combination of 1-copper (I) alkyne and molecular iodine was well used as a synthetic equivalent of 1-iodoalkyne without the need for tedious preparation, purification, and storage of 1-iodoalkyne.