Antileishmanial chalcones: statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis

…, SB Christensen, G Cruciani, A Kharazmi…

文献索引：Nielsen, Simon Feldbaek; Christensen, Soren Brogger; Cruciani, Gabriele; Kharazmi, Arsalan; Liljefors, Tommy Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4819 - 4832

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被引用次数: 332

摘要

A large number of substituted chalcones have been synthesized and tested for antileishmanial and lymphocyte-suppressing activities. A subset of the chalcones was designed by using statistical methods. 3D-QSAR analyses using 67 (antileishmanial activity) and 63 (lymphocyte-suppressing activity) of the compounds for the training sets and 9 compounds as an external validation set were performed by using the GRID/GOLPE ...