Spin trapping of C-and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives

…, N Rohr-Udilova, T Rosenau, A Hofinger…

文献索引：Stolze, Klaus; Rohr-Udilova, Natascha; Rosenau, Thomas; Hofinger, Andreas; Kolarich, Daniel; Nohl, Hans Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 10 p. 3368 - 3376

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被引用次数: 22

摘要

In order to develop spin traps with an optimal ratio between hydrophilic and lipophilic properties, low toxicity, and high stability of spin adducts (especially with superoxide radicals), several EMPO-derived spin traps have recently been synthesized forming more stable superoxide adducts (t1/2> 20min) than DMPO or DEPMPO. In this study, ESR-, 1H-, and 13C-NMR data of several phenyl-or n-pentyl-substituted EMPO derivatives are ...