Natural products as sources of new fungicides (I): synthesis and antifungal activity of acetophenone derivatives against phytopathogenic fungi

…, HF Fan, YQ Gao, H Li, AL Zhang…

文献索引：Ma, Ya-Tuan; Fan, Hua-Fang; Gao, Yu-Qi; Li, He; Zhang, An-Ling; Gao, Jin-Ming Chemical Biology and Drug Design, 2013 , vol. 81, # 4 p. 545 - 552

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被引用次数: 12

摘要

Several series of 45 acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by 1H and 13C NMR spectroscopy, HRMS and single-crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate assay. Of them, 12 derivatives (eg, 3a–c, 4c and 4e) exhibited more potent antifungal effects on ...