Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy

…, MK Moon, SH Han, SK Yeon, JW Choi…

文献索引：Woo, Seo Yeon; Kim, Ji Hyun; Moon, Mi Kyeong; Han, Se-Hee; Yeon, Seul Ki; Choi, Ji Won; Jang, Bo Ko; Song, Hyo Jung; Kang, Yong Gu; Kim, Jin Woo; Lee, Jaeick; Kim, Dong Jin; Hwang, Onyou; Park, Ki Duk Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1473 - 1487

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被引用次数: 37

摘要

Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant enzyme genes. We have ...