Tetrahedron

Synthesis of Enantiopure N-and C-Protected homo-β-Amino Acids by Direct Homologation of α-Amino Acids¶

R Caputo, E Cassano, L Longobardo, G Palumbo

文献索引：Caputo, Romualdo; Cassano, Ersilia; Longobardo, Luigi; Palumbo, Giovanni Tetrahedron, 1995 , vol. 51, # 45 p. 12337 - 12350

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被引用次数: 97

摘要

Enantiopure N-and/or C-protected homo-β-amino acids are prepared readily and in good yields from N-protected α-amino acids with the same side chain, via reduction of the carboxyl function and conversion of the resulting N-protected β-amino alcohol into the corresponding β-amino iodide and then β-amino cyanide. The key step of this strategy is represented by the synthesis of the enantiopure N-protected β-amino iodides 2 and 3 that ...