Tetrahedron letters

N-chloro-N-sodio-2-trimethylsilyl ethyl carbamate: A new nitrogen source for the catalytic asymmetric aminohydroxylation

KL Reddy, KR Dress, KB Sharpless

文献索引：Reddy, K. Laxma; Dress, K. Ruprecht; Sharpless, K. Barry Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3667 - 3670

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被引用次数: 52

摘要

The use of N-chloro-N-sodio-2-trimethylsilyl ethyl carbamate in the osmium-catalyzed asymmetric aminohydroxylation of alkenes leads to enantiomerically enriched N- trimethylsilylethoxycarbonyl (TeoC) protected aminoalcohols in yields up to 80% and ee's up to 99%.