Mutagenesis

Metabolic activation of the genotoxic environmental contaminants 2-and 3-nitrofluoranthene in variants of Salmonella typhimurium TA98

…, LM Stocking, MJ Kohan, SH Warren, J Lewtas

文献索引：Ball, L. M.; Stocking, L. M.; Kohan, M. J.; Warren, S. H.; Lewtas, J. Mutagenesis, 1995 , vol. 10, # 6 p. 497 - 504

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被引用次数: 10

摘要

Abstract The mutagenic environmental pollutants 2-nitrofluoran-thene (2-NFA) and 3- nitrofluoranthene (3-NFA), labelled with 3 H and 14 C respectively, were incubated with Salmonella typhimurium strain TA98, its nitroreductase-deficient variant TA98NR and its 0- acetytransferase-deficient variant TA98/1, 8-DNP 6, to investigate the activity of these metabolic pathways under conditions approximating those of the Ames assay, hence their ...