Therapeutic effects of cantharidin analogues without bridging ether oxygen on human hepatocellular carcinoma cells

CB Yeh, CJ Su, JM Hwang, MC Chou

文献索引：Yeh, Chao-Bin; Su, Chi-Jung; Hwang, Jin-Ming; Chou, Ming-Chih European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3981 - 3985

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被引用次数: 22

摘要

Previous research indicates that cantharidin, norcantharidin and their analogues exhibit anticancer activity due to their inhibition of cancer cell lines such as HL60, HT29 and L1210. The anticancer activities of cantharidin, norcantharidin and their analogues involve the suppression of serine/threonine protein phosphatases (PPs) activity. However, cantharidin is not suitable for cancer therapy because of its high cytotoxicity in vitro (IC50= 21 μM in ...