Design, synthesis and antihypertensive screening of novel pyridazine substituted s-triazin-2-imine/one/thione derivatives

R Mishra, AA Siddiqui, A Husain…

文献索引：Mishra, Ravinesh; Siddiqui, Anees A.; Husain, Asif; Rashid, Mohd.; Goda, Chirag Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 3 p. 552 - 559

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被引用次数: 3

摘要

Some new 7-substituted-phenyl-3, 4, 8, 9-tetrahydro-2 H-pyridazino [1, 6-a][1, 3, 5] triazin-2- imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds were screened for antihypertensive activities by non-invasive method using Tail Cuff method. All the test compounds showed significant antihypertensive activity; 7-(biphenyl-4-yl)-3, 4, 8, 9-tetrahydro-2 H-pyridazino [ ...