Abstract ortho-Prenylphenols and its derivatives occur frequently in plants and microorganism, 2) and have been assumed to be essential intermediates in the biosynthesis of some natural products. ortho-Prenylphenols have been synthesized by the Friedel-Crafts reaction of prenyl alcohols or prenyl halides with phenols, 3)-6) or by direct alkylation of phenols with polyprenyl halides in the alkaline media. 7) These reactions had no
