Fluorinase??Coupled Base Swaps: Synthesis of [18F]??5′??Deoxy??5′??fluorouridines

…, LF Schweiger, D O'Hagan

文献索引：Winkler, Margit; Domarkas, Juozas; Schweiger, Lutz F.; O'Hagan, David Angewandte Chemie - International Edition, 2008 , vol. 47, # 52 p. 10141 - 10143

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被引用次数: 27

摘要

The application of positron emission tomography (PET) for medical imaging and diagnostics [1] is a rapidly growing area, and cyclotrons are being increasingly commissioned in major hospitals. Developing methods for the introduction of the appropriate isotopes (11C, 13N, 18F, and 15O) into organic structural motifs is a major research activity at present.[2] The relatively long half-life of 18F (t1/2= 110 min) renders it an attractive radioisotope for PET, ...