Journal of Fluorine Chemistry

Synthesis and biological evaluation of new barbituric and thiobarbituric acid fluoro analogs of benzenesulfonamides as antidiabetic and antibacterial agents

HM Faidallah, KA Khan

文献索引：Faidallah, Hassan M.; Khan, Khalid A. Journal of Fluorine Chemistry, 2012 , vol. 142, p. 96 - 104

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被引用次数: 20

摘要

A novel series of benzenesulfonamide derivatives of barbituric and thiobarbituric acids (2– 12) were synthesized by condensation and cyclization reactions of various ureido and thioureido derivatives of sulfanilamides. Different substituents have been incorporated at C- 5 of barbituric and thiobarbituric acid. Fluoro-and trifluoroacetyl substituents have been installed on various positions and their comparative biological screening was performed ...