Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach

…, TR Bhardwaj, J Haupenthal, RW Hartmann…

文献索引：Aggarwal, Saurabh; Thareja, Suresh; Bhardwaj; Haupenthal, Joerg; Hartmann; Kumar, Manoj European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 728 - 739

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被引用次数: 14

摘要

In the present study, novel steroidal 17a-substituted 3-cyano-17a-aza-D-homo-3, 5- androstadien-17-ones (12–19) and 17a-substituted 17-oxo-17a-aza-D-homo-3, 5- androstadien-3-oic acids (20–26) were synthesized from dehydroepiandrosterone acetate (6) along with 17-oxo-19-nor-3, 5-androstadien-3-oic acid (30) through a multistep synthesis. Compounds were evaluated for their in vitro 5α-reductase inhibitory activity by ...